Living with Factor X Deficiency
Factor X deficiency is a rare bleeding disorder. It is caused by having too little of a protein called factor X in the blood.1,2
- Factor X plays an important role in blood clotting (coagulation)
- People with factor X deficiency have a higher risk of excess bleeding
Factor X Deficiency Can Be Hereditary
Factor X deficiency can be caused by a genetic defect that is passed down from parents to their children.1,2
- To have hereditary factor X deficiency, a person must receive a defective factor X gene from both parents
- Hereditary factor X deficiency affects approximately 1 in every 500,000 people
Symptoms of Factor X Deficiency
The symptoms of factor X deficiency can range from mild to severe. Women may experience additional symptoms as compared with men.1,2
Symptoms of severe factor X deficiency may include:
- Joint bleeds and bruising
- Spontaneous bleeding in the head, spinal cord, or gastrointestinal tract (for example: stomach or intestines)
Symptoms of mild factor X deficiency may include:
- Easy bruising
- Mouth bleeds
- Bleeding longer than normal after injury or surgery
Women with factor X deficiency may experience:
- Heavy or prolonged bleeding during menstruation (periods)
- Complications during pregnancy or childbirth
Diagnosing Factor X Deficiency
A healthcare provider may suspect a bleeding disorder like factor X deficiency based on:
- A personal history of bleeding symptoms
- A family history of a bleeding disorder
When factor X deficiency is suspected, the diagnosis is made through blood tests that measure the time it takes for blood to clot. An additional test that measures the activity of factor X in the blood can be used to confirm the diagnosis.1,3
References: 1. National Hemophilia Foundation. Factor X. https://www.hemophilia.org/Bleeding-Disorders/Types-of- Bleeding-Disorders/Other-Factor-Deficiencies/Factor-X. Accessed June 8, 2017. 2. MedlinePlus Medical Encyclopedia. Factor X deficiency. https://medlineplus.gov/ency/article/000553.htm. Accessed June 8, 2017. 3. MedlinePlus Medical Encyclopedia. Factor X assay. https://medlineplus.gov/ency/article/003680.htm. Accessed June 8, 2017.
Indications for COAGADEX
COAGADEX, a plasma-derived blood coagulation factor X concentrate, is indicated in adults and children (aged 12 years and above) with hereditary factor X deficiency for:
- On-demand treatment and control of bleeding episodes
- Perioperative management of bleeding in patients with mild hereditary factor X deficiency
Limitation of Use
Perioperative management of bleeding in major surgery in patients with moderate and severe hereditary factor X deficiency has not been studied.
Important Safety Information for COAGADEX
COAGADEX is contraindicated in patients with known hypersensitivity to any of the components of the product.
Allergic type hypersensitivity reactions, including anaphylaxis, are possible with COAGADEX. If symptoms occur, patients should discontinue use of the product immediately and contact their physician.
The formation of neutralizing antibodies (inhibitors) to factor X is a possible complication in the management of individuals with factor X deficiency. Carefully monitor patients taking COAGADEX for the development of inhibitors by appropriate clinical observations and laboratory tests.
COAGADEX is made from human plasma and may contain infectious agents, e.g. viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. No cases of transmission of viral diseases, vCJD or CJD, have been associated with the use of COAGADEX.
In clinical studies, the most common adverse reactions (frequency ≥5% of subjects) with COAGADEX were infusion site erythema, infusion site pain, fatigue and back pain.
Please see Full Prescribing Information for complete prescribing details.
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