Could your bleeding or other symptoms be due to hereditary factor X deficiency?

Hereditary factor X (10) deficiency is a rare bleeding disorder that can be serious. It affects about 1 in 12 people with a rare bleeding disorder. If you have factor X deficiency—or think you might—this page is for you.

Here, you can:

What Is Factor X Deficiency?

Factor X deficiency (spoken as “factor 10”) is a rare bleeding disorder. It is caused by having too little of a clotting factor called factor X in the blood. Or sometimes, people have enough factor X but it does not work the way it should. Hereditary factor X deficiency is factor X deficiency that runs in families, meaning it can be passed down from parents to a child.

Factor X works by helping with blood clotting to slow and stop bleeding. Bleeding can happen inside the body (for example, in a joint) or on the outside of the body (as with a skin cut). People with factor X deficiency may bleed more than normal and have a hard time getting bleeding to stop.

Symptoms of factor X deficiency sometimes can be confusing or hard to understand. For example, symptoms may include joint swelling and pain that are caused by bleeding inside a joint.

Graphic depicting continuous bleeding when there's not enough clotting factor

Symptoms of factor X deficiency may include—

Woman icon

Symptoms in women:

  • Heavier or longer bleeding during periods than most other women (heavy menstrual bleeding)
  • Bleeding complications during pregnancy or childbirth
Newborn baby icon

Symptoms in newborns: Umbilical cord (belly button) or circumcision bleeding that does not stop normally, or brain or stomach bleeding

Symptoms in anyone:

  • Bruising on skin illustration icon
    Easy bruising
  • Nose bleed illustration icon
    Nosebleeds
  • Bleeding in joints illustration icon
    Joint swelling/pain
  • Bleeding gums illustration icon
    Gum bleeding
  • Excessive bleeding from injury illustration icon
    Excessive bleeding after injury
  • Internal bleeding in brain illustration icon
    Bleeding in the brain

What about pain?

Bleeding disorder symptoms can cause discomfort.

  • People with bleeding disorders sometimes have pain with their bleeding symptoms.
  • The pain can happen for different reasons, like swelling from bleeding in a joint, or bruising.
  • It is important to tell your doctor about all your symptoms, so they understand how much bleeding affects you.
Ask your doctor about testing for bleeding disorders if you have these symptoms.

Patient and Caregiver Stories—Journey to Diagnosis

Photo of Adrian, who has factor X deficiency

Adrian’s Story:

“After more than 25 years of bruising and pain, I was finally diagnosed with factor X deficiency.”

Read More

Photo of Maritza, who has factor X deficiency

Maritza’s Story:

“As I matured, I started having heavy menstrual flows that caused me to miss school and social activities.”

Read More

Photograph of Carly, mother to Ariel who has factor X deficiency

Carly’s Story:

“We felt alone, afraid, and ill-equipped to raise an infant with a life-threatening condition.”

Read More

Photograph of Pam, whose son, Reece has factor X deficiency

Pam’s Story:

“I learned that if you don’t get up and advocate for yourself and your family, then nothing will happen.”

Read More

How Do I Know if I Have Factor X Deficiency?

Talk with your doctor if you think you may have factor X deficiency. Your doctor may ask about your symptoms, medical history, and family history of bleeding problems. A simple blood test is all that is needed to determine if you have hereditary factor X deficiency.

Testing illustration icon
The only way to be sure if you have a bleeding disorder, including hereditary factor X deficiency, is to be tested using a simple blood test.

Help your doctor help you.

  1. Answer a few symptom questions and save, print, or email your answers.
  2. Show the questions and answers to your doctor.
  3. Ask your doctor about getting tested for bleeding disorders.

Early diagnosis of bleeding disorders is important. Bleeding disorders like factor X deficiency can cause serious or life-threatening problems, such as stroke or miscarriage. They can also cause a lifetime of discomfort and pain.

Ask your doctor about blood tests to find the cause of your bleeding or other symptoms.

How Is Hereditary Factor X Deficiency Treated?

Hereditary factor X deficiency is treated by replacing the factor X that is missing in the body. How often treatment is needed depends on how often you have symptoms and how severe they are.

Calendar and clock icon

Routine treatment:

  • Routine treatment means you take a medicine regularly as directed by your doctor to help prevent bleeding before it happens.
    Near-normal levels of factor X are always in the blood
    Illustration of Factor X in the blood to control bleeding for preventative treatment
  • This may be the right choice if your symptoms are regular, affect your daily activities, are painful, or if you have severe (bad) bleeds.
Blood droplet and hand icon

Treatment as needed (on-demand):

  • You may decide to treat each time you bleed. As-needed treatment can help to stop a bleed after it starts.
    Factor X is given to raise levels to stop bleeding
    Illustration of extra Factor X in the blood to stop non severe bleeding for on-demand treatment
  • This may be the right choice if you bleed very rarely, if bleeding does not affect your daily activity, or if your bleeding is not severe.

Treatment with surgery:

  • Treatment may be given to help prevent bleeding with surgeries.
  • This may be the right choice even if you bleed rarely or your bleeding is not severe, or your daily activity is not usually affected by it.
Doctor icon
If you have hereditary factor X deficiency, replace the factor X that is missing with COAGADEX.
Ask your doctor if COAGADEX is right for you.

Indications and Usage for COAGADEX

COAGADEX, a plasma-derived blood coagulation factor X concentrate, is indicated in adults and children with hereditary factor X deficiency for:

  • Routine prophylaxis to reduce the frequency of bleeding episodes
  • On-demand treatment and control of bleeding episodes
  • Perioperative management of bleeding in patients with mild and moderate hereditary factor X deficiency

Limitation of Use

Perioperative management of bleeding in major surgery in patients with severe hereditary factor X deficiency has not been studied.

Contraindication for COAGADEX

COAGADEX is contraindicated in patients who have had life-threatening hypersensitivity reactions to COAGADEX.

Important Safety Information for COAGADEX

Allergic type hypersensitivity reactions, including anaphylaxis, are possible with COAGADEX. If symptoms occur, patients should discontinue use of the product immediately, contact their physician, and administer appropriate treatment.

The formation of neutralizing antibodies (inhibitors) to factor X is a possible complication in the management of individuals with factor X deficiency. Carefully monitor patients taking COAGADEX for the development of inhibitors by appropriate clinical observations and laboratory tests.

COAGADEX is made from human plasma and may contain infectious agents, e.g. viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. No cases of transmission of viral diseases, vCJD or CJD, have been associated with the use of COAGADEX.

In clinical studies, the most common adverse reactions (frequency ≥5% of subjects) with COAGADEX were infusion site erythema, infusion site pain, fatigue and back pain.

Please see complete Prescribing Information for COAGADEX.